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However, when Δ9-THC is obtained from an extraction process, extraction of cannabinoids is usually not complete, which complicates estimates of dosage in the resulting cannabis-infused oil. The Δ9-THC dose in homemade products depends upon the concentration of THCA in the plant from which it is extracted or the Δ9-THC concentration in purchased oil. The fact that users of edibles often unintentionally ingest greater than intended amounts of Δ9-THC demonstrates the difficulty of dose titration with edibles, an issue that is not typically of concern with smoked cannabis due to its rapid distribution into the brain. The lack of consistency and the delayed intoxication may cause both new and experienced users of cannabis to consume higher than intended amounts of the drug. Indeed, compared with smoking or intravenous infusion, with oral administration of cannabis the Δ9-THC concentration in the plasma is lower and the correlation between the plasma concentration of Δ9-THC and degree of intoxication varies considerably across individuals (Hollister et al., 1981). When inhaled through smoking or vaping, Δ9-THC reaches the brain, takes initial effect within minutes, and shows peak effect in about 20 to 30 minutes, with psychoactive effects tapering off within 2 to 3 hours (Grotenhermen, 2003; Huestis, Sampson, Holicky, Henningfield, & Cone, 1992). From the gut, Δ9-THC is absorbed into the bloodstream and travels via the portal vein to the liver, where it undergoes first-pass metabolism. 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