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This advice is similar to that for other fibers, which can cause untoward GI side effects, particularly if large amounts are consumed without a stepped-up dosing regimen to allow for acclimation. The mucilage can then affect satiety as well as nutrient digestion, absorption, and metabolism in the GI tract . Glucomannan is a non-digestible carbohydrate that has been approved for labeling as a dietary fiber by the FDA based on its ability to attenuate cholesterol levels . Glucomannan is a high molecular-weight polysaccharide mainly composed of d-mannose and d-glucose linked by β-1,4 glycosidic bonds with side chains . In the same study, 2-week supplementation with 2.6 g/day of choline (provided as phosphatidylcholine) increased serum TG by (8%) but did not alter TC, LDL-C, or HDL-C. High levels of TMAO have been linked to detrimental vascular and inflammatory effects in animal and cell culture studies. Choline serves as a dietary precursor for the gut microbial-generated trimethylamine (TMA), which is oxidized by the hepatic enzyme flavin-containing monooxygenase 3 (FMO3) to form trimethylamine-N-oxide (TMAO) [104,105]. The DGA 2020–2025 has addressed choline nutriture and noted that choline intake needs to be higher during pregnancy and lactation for replenishment of maternal stores and support for fetal development, particularly of the brain and spinal cord . Average dietary choline intake in several countries has been reported to be below recommendations for most populations and age/sex groups, ranging from 230–468 mg/day for adults, and mostly from animal-based food sources . Specifically, choline is involved in metabolic pathways for the synthesis of acetylcholine, betaine, phospholipids, and trimethylamine, which, in turn, play roles in lipid transport, membrane synthesis, neurotransmission, and one-carbon metabolism [88,89]. 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