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The procedure that 17 participants (5 males and 12 females) underwent, two glucose tests and three sample gummies tests (CG, P-SG and T-SG), is displayed in Figure 4. This prospective crossover study enrolled healthy adults and was conducted from July 2020 to September 2020. In part, this is due to the texture differences created by the sweeteners used in the gummies, which affects digestive behaviors and the subsequent glucose release after oral administration. Experimental results showed that, compared with high-GI food, low-GI gummies exhibited significantly improved postprandial glycemia, regardless of available carbohydrate levels. Furthermore, the P-SG and T-SG provided healthier options for people in control of glucose homeostasis. All the gummies were low-GL foods, and gummy format counteracted glucose intolerance in females. Thus, the differences in blood glucose levels may be largely attributed to the different digestive release behavior of sweeteners from gummies. Hence, in order to confirm the main cause of the difference in metabolism capacity between males and females, carbohydrates need to be assigned according to lean body mass in future studies. It can be explained by the insulin-independent characteristic of these low-GI gummies, suggesting that low-GI foods are more conducive to maintaining female glucose homeostasis. In previous reports, it has been demonstrated that the correlation between visceral fat content and glucose homeostasis in women is significantly higher than that in men. Gummies with low GI values (P-SG and T-SG) demonstrated a significantly lower AUC than gummies with a high GI value (CG), even though the amount of available carbohydrate was the same in all cases. Because of this unique metabolic characteristic, it is frequently used in common and functional foods for people with special health demands, such as diabetic and obesity patients. In addition to the gelling properties of different types of gummies, the distinction in GI value of the sweeteners within them could also affect blood glucose levels. The results of the in vitro release study that CG did present a significantly higher release of glucose than P-SG and T-SG supported above assumptions. It has been explained by McClements that gummies contain hydrocolloids that may increase the viscosity of the gastrointestinal fluids, thereby slowing the mixing and mass transfer process, and altering the flavors or nutrients release . 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