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Moreover, co-ingestion of creatine with carbohydrate [47,183] or creatine with carbohydrate and protein has been reported to increase creatine uptake and/or muscle glycogen levels [47,184,185]. Rae et al. found that working memory and processing speed increased with creatine supplementation (5 g/day for 6 weeks). Consequently, research has examined whether creatine supplementation affects cognition, memory, and/or executive function in older individuals as well as patients with mild cognitive impairment [94,168,174,177,178].