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GG-PI uses inexpensive standard classical simulations or existing data for training and allows transfer across temperatures without retraining. An empirical application to latent group panel structures using health administrative data shows that the proposed approach reduces out-of-sample prediction error by approximately 17.6% relative to the best results obtained from standard MLE procedures. When used to initialize DFT calculations, ELECTRAFI reduces total DFT compute cost by up to ~20%, whereas slower charge density models negate savings due to high inference times. Through this complementary mechanism, the combined testing of CRP and PCT not only improves the diagnostic accuracy for fracture-related infections but also effectively predicts clinical outcomes, providing a more reliable basis for personalized treatment. In case of critically ill patients with a high probability for bacterial infection early empiric antibiotic therapy is crucial and PCT is mainly used for treatment cessation, based on its kinetics. A more recently published international expert consensus, recommended PCT cut-off levels for critically ill patients in order to estimate the probability of bacterial infections and therefore, improve initial clinical assessment (Figure 2) (21). This in turn, has not only a high impact on decisions regarding treatment of patients with suspected infections or sepsis (20), but can also influence the duration of antibiotic treatment courses. However, due to the limited studies available for comparison, it is imperative that more large-scale prospective investigations are required to compare the diagnostic accuracy of PCT and CRP in differentiating infections among non-neutropenic cancer patients. 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