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Immunomodulation occurredvia suppression of IL-4, IL-8, and TNF-α while enhancing expressionof IL-10 and soluble ICAM (sICAM).485 Moreover,treatment with 100 mg of curcumin in combination with isoflavonesfor 6 months produced an anti-androgen effect by decreasing the levelof PSA in 85 patients who did not have prostate cancer.486 Curcumin (350 mg) in combination with calendulaextract (80 mg) for 1 month remarkably reduced pain and inflammatorycytokine expression in patients with chronic prostatitis or chronicpelvic pain syndrome type III.487 A studyshowed that supplementation with phospholipidated curcumin (500 mg/day,twice daily) and glucosamine (500 mg/day Regenasure, twice daily)improved the Karnofsky index, the WOMAC score, and treadmill walkingdistance in patients with osteoarthritis of the knee.455 Also, the administration of curcuminoids withglycosaminoglycans in osteoarthritis decreased pain and joint stiffness.456 Similar outcomes in improved pain and jointstiffness were reported by Panahi et al. in 40 cases of osteoarthritistreated with 1500 mg of C3-complexed curcumin daily for 6 weeks. The combined therapy was also shown to improve clinicalpresentation.442 In another study involving11 patients suffering from Crohn’s disease or UC, the effectof curcumin was investigated for its potential as an adjunct to conventionaltherapies. The patients with ulcerative proctitis experienceda decrease in abdominal pain, cramping, and muscle soreness, whilethose with Crohn’s disease experienced a reduction in Crohn’sDisease Activity Index scores and sedimentation rates.440 Patients with ulcerative colitis (UC) who consumed2 g of curcumin (1 g each after breakfast and the evening meal) plussulfasalazine (SZ) or mesalamine daily experienced a decrease in diseasemorbidity, and the treatment was found to be safe.441 Similarly, a study by Lang et al. showed that taking curcuminwith mesalamine (3 g) for a month was safe with no reported adverseeffects in UC. 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