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However, the application of a Persian medicine polyherbal formula (Nigella sativa seed oil, Olea europea oil and oleo-gum-resin of Boswellia sacra Flueck) did not show any benefit intra-group or compared to placebo for IELT or PEDT . Although the mechanisms of action of SS-Cream have yet to be determined, it is proposed that the active constituents of the included herbs act as desensitizing agents on the glans penis, smooth muscle relaxation and increased local blood flow that may be mediated through the activation of NO/guanosine monophosphate pathways . Furthermore, QSF has been shown to increase low baseline levels of NO and serotonin and decrease high baseline levels of testosterone and oxytocin in PE patients, with no effect on FSH, LH, prolactin and thyroid-stimulating hormone . 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