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Several non-pharmaceutical methods may help increase blood flow to the penis naturally. Androgen receptor (AR) is abundantly expressed in male genital tissues and in spermatozoa,56 and its expression is significantly decreased in infertile men.57 Ginsenoside Rb1 and Re have been reported to be AR agonists, through which these ginsenosides stimulate NO production via the activation of NOS.58,59 Ginseng berry extract GB0710, of which ginsenoside Re is the key ingredient, could improve erectile dysfunction in rats by inducing NO production.10 Re-induced NO production in sperm has also been shown to be involved in capacitation and acrosome reaction, and that these effects could be a result of the non-genomic activities of the Re-AR interaction.40