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The coexistence of the two conditions, obesity and dietary supplements, together with the use of medicines for other health problems, justifies the need to be aware of the potential interactions that exist between dietary supplements and medicines and to define the role of the pharmacist in order to avoid, as far as possible, risk situations for the patient. Although the efficacy of most dietary supplements for weight control is highly controversial, with conflicting scientific evidence and unclear mechanisms of action, their use is increasing steadily. The long-term use of these dietary supplements makes it highly likely that they will be combined with medications, increasing the risk of food supplement–drug interactions, which are not always known or disclosed, and can lead to serious health problems, as has been observed. Some keto gummies may interact with blood pressure medications, which can increase the risk of side effects. 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