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Estradiol, the most potent female sex hormone, fluctuates throughout a woman's life and menstrual cycle. Data were analyzed using a random-effects model and presented as weighted mean differences (WMDs) with 95% confidence intervals (CIs). A comprehensive literature search was conducted across PubMed/Medline, Embase, Web of Science, and Scopus to identify relevant studies published before June 11, 2024. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. 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