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So it would not be unreasonable to say that after a significant weight loss, a person’s penis might appear to be larger than it did previously. Just like any other part of the body, when one’s weight changes, it makes the body look different than it did before the weight loss or gain. “The evidence is now irrefutable that growth hormone (GH), long thought to be a single substance, is actually a mixture of several different forms. In turn, only a small subset of these exercise studies considered the issue and importance of GH assay choice employed and the large difference it can make in interpreting experimental data. Most studies show baseline AR protein content does not change although one study found significant down-regulation (85) and one study reported up-regulation in older men (30). The concentration of ARs in skeletal muscle depends on the muscle fiber type, sex, training status, and androgen concentrations. 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