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Thus far, large dietary clinical trials in humans and also experiments in rodents are lacking that properly investigate the effect of a ketogenic diet on weight loss and gut microbiota composition and function. The ketogenic diet is popular due to its potential to induce rapid weight loss [7,78], which can also affect gut microbiota composition and function . Interestingly, the gut microbiota has been implicated in all these factors and likely plays a crucial role in mediating, at least in part, the beneficial effects of a ketogenic diet on metabolic health. The beneficial effects of the ketogenic diet on weight reduction and the exact role of the gut microbiota remains elusive. To date, no preclinical studies investigated the effects of a ketogenic diet on the gut microbiota and body weight. It is also possible that the gut microbiota are involved in mediating weight loss through a ketogenic diet . The ingredients commonly found in keto gummies, such as healthy fats and sugar substitutes, align with the macronutrient composition of a ketogenic diet. The picture (Figure 2) aims to highlight the supposed major effects of ketogenic diet on different tissues and gut microbiota, along with how tissues may be influenced by gut microbiota diversity. The terms combined with Boolean operators AND, OR, NOT have been “gut microbiota”, “gut microbiome”, “intestinal microbiome”, “ketogenic diet”, with “ketogenic”, “fat”. The aim of this review is to dissect the complex interactions between ketogenic diet and gut microbiota and how this large network may influence human health. These ingredients are used to sweeten the gummies without adding carbs, but they can be hard on the stomach, especially when consumed in large quantities. Keto gummies often contain sugar alcohols like erythritol or xylitol, which can cause digestive issues such as gas, bloating, and diarrhea for some people. 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