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Sugars in total and partial sugar substitutes gummies, T-SG and P-SG, were substituted by erythritol and maltitol, while sucrose-based gummies were used as comparisons (CG). It was discussed above that GI and GL values are highly dependent on available carbohydrates, so, in this study, we maintain consistent carbohydrate levels across samples (the same theoretical glucose conversion content). This study aimed to explore the effect of sugar alternatives and dosage form of gummies on glycemic response. As far as we know, it is still unclear how maltitol and erythritol affect the structure of gummies and how they affect humans’ blood sugar homeostasis. In general, a higher carbohydrate content causes a greater response to blood glucose levels. Available carbohydrate is defined as the content of carbohydrate that can produce glucose and be absorbed by the small intestine. 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