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The availability of these PDE-5 inhibitors has provided effective and well-toleratedoral treatments for ED.5,7,15,16 Moreover, these drugs havebeen reported to improve endothelial function, 10,14 and are speculated to havevascular and myocardial protective properties.10,17 As a class, the three drugsare indicated for the treatment of erectile dysfunction only. Although these EDMs have been FDA approved to treat ED, mounting evidence indicates that these drugs have become increasingly used as a sexual enhancement aid among men without a medical indication. The interventional non-inferiority proACT trial revealed low adherence rates to the PCT protocol, indicating a shortcoming of experience in the use of PCT as well as in its interpretation in a clinical context. A more widespread use of PCT in critically ill patients was limited by the fact, that a commonly accepted algorithm for the utilization of PCT in those patients was long lacking (21). 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