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This section collects any data citations, data availability statements, or supplementary materials included in this article. Null results were reported for SBP and DBP in two meta-analyses of studies in normotensive participants [159,160]. However, HDL-C increased and TG decreased following 4 mg capsaicin/day for 3 months in adults with low HDL-C . Capsaicinoids may also affect food intake, and a meta-analysis of eight studies showed that capsaicinoid ingestion with a minimum dose of 2 mg before a meal significantly decreased ad libitum calorie (−74.0 kcal) during the meal, suggesting an appetite suppression effect . A meta-analysis reported a marginal decrease in BW and BMI when assessing results from four and five studies, respectively . These all represented observational studies, and therefore, no causal relationship can be established from these data. For example, a 2014 meta-analysis reported that low intake of capsaicin showed protection, whereas medium-high intakes showed susceptibility to gastric cancer, but this only searched for studies that assessed chili pepper food and only included case–control design studies . A tolerability study of a proprietary product comprising of a blend of capsaicinoids obtained from Capsicum annuum has been reported as well and showed no change in tolerability at ≤500 mg/day (10 mg/day of capsaicinoids) when provided for 1 week . The ODS has stated that few safety concerns have been reported for ≤33 mg/day for 4 weeks or 4 mg/day for 12 weeks of capsaicin and other capsaicinoids . Average consumption in Korea is ~3.25 mg/day, and consumption in Mexico averages 24.5–32 mg/day, though intake up to 250 mg/day has been reported [135,136]. A similar but independent group of compounds named capsinoids has also been investigated in several clinical trials on weight management . 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