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The potency of dopamine receptor agonists in inducing penile erection not only in male rats but also in men and in facilitating male rat sexual behavior [38,195], also led to testing the clinical use of apomorphine with a preparation to be administered sublingually in patients suffering for erectile dysfunction. In combination with intracerebral microdialysis experiments, the above studies confirmed that penile erection induced by D2 receptor agonists given to the PVN takes place concomitantly with an increase in the PVN nitric oxide production, confirming that dopamine in this hypothalamic nucleus facilitates erectile function by activating nitric oxide synthase located in the cell bodies of oxytocinergic neurons that project to extrahypothalamic brain areas and the spinal cord mediating penile erection (Figure 2). 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