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Interestingly, the facilitatory effect on non-contact erection by these drugs takes place with a concomitant increase in extracellular dopamine in the nucleus accumbens dialysate, the dopamine increase being higher in male rats screened for not showing non-contact erections than in those showing the sexual responses . This discovery was soon followed by studies showing that NO plays a role in erectile function (discussed above) and sexual behavior also at the central level [37,38,41]. This is due to the key role of NO in the activation of guanylate cyclase and the consequent increase in cGMP levels that are responsible for the relaxation of the cavernous corpora smooth muscles allowing penile erection to occur (see Section 1). The FDA has warned consumers about male enhancement products containing hidden substances that may lead to serious health concerns. 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