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We reported that a single dose of MPH resulted in significant depression of neuronal excitability and synaptic transmission in the prefrontal cortex; treatment with a chronic regimen of 3 weeks resulted in even further depression (Urban et al., 2012). These pioneering studies have yielded striking results, indicating that early life treatment with MPH may alter circadian rhythms, induce anxiety that persists into adulthood, and even impair object-recognition memory (Lee et al., 2009; Algahim et al., 2010). Thus, one must examine the research on MPH as a cognitive enhancer and studies using normal individuals with caution. Currently, there is no reliable method for determining optimal levels of these neurotransmitters in living human brains; thus, predicting how a certain dose of MPH will affect a particular person is largely an educated approximation. 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