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Immediate cyclic stretching decreased the degree of alignment of both collagen and SFs towards the constrained direction, with this decrease dependent on the amplitude of the applied cyclic stretch (Fig. 7B–D,F–H, J–L and N–P). In case of external cyclic stretch applied in the constrained direction, the alignment of both SFs (B–D and J–L) and collagen (F–H and N–P) decreases when the stretch amplitude increases (from left to right). A quarter of males and 30.7% of females who had never experienced an adverse event thought that they would consult with a doctor (clinic), but only 1.2% of males and 3.3% of females consulted with a doctor (clinic) among those who had experienced adverse events. 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