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The ginsenoside Re-induced motility enhancement effect in spermatozoa could be related to the findings that Re is found to be both ER and PR agonists.58 Coli are the most frequent pathogens isolated fromejaculates of patients with MAGI. The gastrointestinal microbiome plays an important role in theimmune system, and dysbiosis of the gastrointestinal microbiota can lead to systemicinflammation (Tilg & Kaser,2011). Deviations from the “normal” human gutmicrobiome have been discovered in a variety of diseases and conditions, includinginflammatory bowel disease, colorectal cancer, obesity/metabolic syndrome, type 2diabetes mellitus, breast cancer, autoimmune disease, autism spectrum disorder,post-traumatic stress disorder, and responsiveness to visceral pain (Li et al., 2016). 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