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The trial by Hogl et al.27 was the major contributor to the heterogeneity of the change in quality of life, possibly because it used a significantly longer treatment duration compared with other trials. Except for the two trials26,29 in which the rate of loss to follow-up of placebo group was higher than that of pramipexole group, and the two trials24,29 in which the proportion of females in placebo group was higher than the proportion in pramipexole group, the baseline data of all other trials were completely comparable between the two groups. This study demonstrated that for patients with primary moderate to severe RLS, pramipexole showed a higher treatment efficacy compared with placebo for eight endpoints, including the change in the IRLS scores, the proportion of patients whose IRLS score decreased by at least 50% after treatment, CGI-I, PGI, the change in quality of life, the change in daytime tiredness, the change in periodic limb movements during sleep and the change in quality of sleep. The Egger test derived a p value less than 0.05 for the change in quality of sleep, indicating the existence of a publication bias for this endpoint. 2 Pack Alpha Horse Capsules, Alpha Horse Official Male Formula Pills With ingredients like Tongkat Ali, L-Arginine, and Zinc, this product aims to improve blood flow, stamina, and overall sexual health. Brazilian Wood is a specially formulated supplement designed to boost men’s health, particularly for improving sexual performance and combating erectile dysfunction (ED). 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