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In summary, supplements providing caffeine, GTE, GCBE, choline, glucomannan, and/or capsaicinoids and capsainoids may provide some benefit for weight management and related measures of metabolic health and are generally safe when used in accordance with the manufacturers’ directions. Nevertheless, these observations are not supported by the results of another meta-analysis that found a non-significant reduction in BW of −0.19 kg , although a limitation of this study is the heterogeneity of the interventions, which include capsaicin supplements and hot pepper foods. Related to supplements, EFSA evaluated phenylcapsaicin, a chemically synthesized analog of capsaicin for use in food supplements and foods for special medical purposes at a maximum of 2.5 mg/day in the general population above 11 years old . Consumers of glucomannan supplements are urged to follow the manufacturer’s consumption instructions, consume adequate liquid with glucomannan products, and be aware of any deficits in swallowing or esophageal anatomy that could increase their risk for esophageal obstruction. The role of the microbiota in healthy weight management is of high interest and in vitro studies have shown konjac fiber may beneficially alter the human gut microbiome ; however, human data on overweight/obese subjects are scarce. In 2010, the EFSA approved a reduction for BW claim for glucomannan at a daily dose of ≥3 g consumed over three eating occasions throughout the day and in the context of an energy-restricted diet in overweight adults . Choline supplementation has been explored in randomized, double-blind, placebo-controlled trials on lipid profiles with no effect seen with 400 mg/day choline in T2DM subjects or with 1 g choline/day in 42 healthy postmenopausal women . 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