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In fact, as men grow older, reduced testosterone levels and decreased blood circulation can lead to a slight reduction in both girth and firmness. Penile girth generally does not increase with age. The availability of these PDE-5 inhibitors has provided effective and well-toleratedoral treatments for ED.5,7,15,16 Moreover, these drugs havebeen reported to improve endothelial function, 10,14 and are speculated to havevascular and myocardial protective properties.10,17 As a class, the three drugsare indicated for the treatment of erectile dysfunction only. 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