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ΒHB mediated the inhibition of NLRP3 inflammasome in lipopolysaccharides (LPS)-stimulated human monocytes leading to a reduced production of interleukin-1beta (IL-1beta) and interleukin-18 (IL-18) without significantly affecting tumor necrosis factor-alpha (TNF-alpha) levels . Reducing HDAC6 levels is mechanistically linked to tubulin-acetylation and improved mitochondria transport . HDAC3 negatively regulates spatial memory in APP/Presenilin 1 (PS1) mice and HDAC3 inhibition might represent a potential therapy for the treatment of AD . HCA2 activation induces a neuroprotective macrophage phenotype related to Prostaglandin D2 (PGD2) production by Cyclooxygenase 1 (COX1), that helps to resolve inflammation and has neuroprotective effects . Acute increase of H2O2 and 4-HNE during the first days of diet activates the release of Nrf2 from Keap 1 to produce an adaptive antioxidant response [52,55]. 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