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Further studies elucidating the molecular mechanisms of a ketogenic diet are in progress in our laboratory. Therefore, these results indicate that the administration of a ketogenic diet for a relatively long period of time is safe. This is a unique study monitoring the effect of a ketogenic diet for 24 weeks. Further studies on the role of a ketogenic diet in antineoplastic therapy are in progress in our laboratory. However, it has been shown that short-term ketogenic diets improve the lipid disorders that are characteristic of atherogenic dyslipidemia (56). These studies provide evidence to explain the actions of a ketogenic diet in the brain. In another study (30), it was shown that a ketogenic diet induced gene expression in the brain. It has also been found that a ketogenic diet affects signal transduction in neurons by inducing changes in the basal status of protein phosphorylation (29). 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