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The HA filler used in this study had a higher degree of cross-linking and HA concentration than the HA fillers used in previous studies, thus increasing the viscosity and cohesivity of the filler, which in turn increases the longevity and tissue volume of the injection site . Although the mechanisms of tissue expansion of the two fillers are different, there was no significant difference in the effects and stability of the two fillers in this study, consistent with the results of previous studies [13,14,15]. By making minimal alterations to the material, manufacturers have created HA products that are well tolerated by the immune system and exhibit favorable properties of longevity and nonreactivity . This enlargement exceeded that of most previously published surgical procedures. 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