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The formation of 2α-OH-T was observed only in CYP3A4 and CYP3A5 incubations when higher enzyme concentrations or significantly longer incubation times were used, leading to conditions outside of the parameters defined by steady-state kinetics (Segel, 1975). For each testosterone concentration, mean metabolite formation rate values obtained from triplicate determinations for the three recombinant CYP3A enzymes were fit to the Michaelis-Menten (hyperbolic) or the Hill (sigmoidal) equation using GraphPad Prism software (version 4.03; GraphPad Software, LaJolla, CA). “The problem with defining the sigma male is that all of their fundamental characteristics are completely made-up by an intensely toxic and misogynistic community that believe in concepts like the social-sexual hierarchy,” explains @phonewifey, a musician and sigma-focused meme-maker. 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