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The fourth smaller study recruiting women prescribed transdermal estrogen showed significant increase in desire and response scales but not in the numbers of sexually satisfying events [Davis et al. 2006b]. Over the past 5 years, seven parallel group RCTs of transdermal testosterone for medically and psychiatrically healthy postmenopausal women with low sexual desire have been published. Serum levels of testosterone do not correlate with women's sexual function according to large epidemiological studies [Davis et al. 2005; Santoro et al. 2005]. Not only would relative resistance of the androgen receptor theoretically impair testosterone activity and contribute to sexual dysfunction, but this could be accompanied by relatively high serum testosterone levels due to lessening of the hypothalamic pituitary ovarian negative feedback. Your health decisions matter to us, and we provide trustworthy guidance to support your choices. 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