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On the other hand, over the past decade, reactive oxygen species have been implicated in the development of male infertility due to their overproduction or a reduced ability of the reproductive system and sperm to deal with it. Due to the support of the World Health Organization for maintaining public health and reproductive health, today the use of medicinal plants as a substitute or supplement to synthetic drugs affecting fertility is considered. Phytoestrogens can also affect estrogen levels in ovarian tissue by interfering with estrogen-synthesizing and metabolism enzymes such as aromatase and estrogen receptors signaling pathways.36 It stated that phytoestrogens are structurally similar to E2.36 In vitro, in vivo, and human studies have proved that phytoestrogens may also control estrogen function by affecting estrogen synthesis and metabolism or hormonal signaling within the hypothalamus-pituitary-gonadal axis. 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