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This, along with the fact that mild depressive episodes are more likely to respond to placebo and the differences noted in the mild/moderate depression severity group in one of the aforementioned studies , indicates that individuals experiencing milder depression may exhibit more pronounced positive outcomes from probiotics. These conflicting findings could partly be attributable to the significant heterogeneity in the strains used in our included studies. It should also be noted that in nearly one third of the included studies (nine studies in total) no significant benefit was noted after the consumption of probiotics, which again is in concordance with other existing data [37,40]. Several of the included studies measured changes in certain metabolites related to the gut microbiome, which is influenced by the probiotic usage, and their association to depression and anxiety. 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