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Based on the above studies, it appears as though chitosan may be effective to help aid weight loss. At the end of the study period, there was no difference in body weight or BMI between the two groups. The data that is available, however, does not demonstrate significant weight loss. The participants were randomized to receive 2.4 grams of Garcinia cambogia (1.2 grams of HCA) or placebo per day, in addition to a low calorie diet. A double-blind, placebo-controlled parallel group study performed by Mattes and Bormann enrolled 89 mildly overweight females to evaluate HCA on weight loss and appetite suppression. In addition, the placebo group demonstrated a decrease in percent body fat mass of 2.16%, and the HCA group demonstrated a 1.44% decrease. Overall, it appears as though that CLA helps to reduce BFM and SAD in patients, but minimal effect on BMI or body weight. Overall, this study demonstrated that CLA use is safe over 24 months and may be beneficial in initial weight loss and may help with maintaining weight loss and reductions in BFM. Gaullier et al. decided to not only evaluate the effectiveness of CLA on weight loss, but to see if either CLA-triacylglycerol or CLA-FFA is more efficacious than the other. Along with other weight related endpoints, this study also evaluated the effects of CLA on sagittal abdominal diameter (SAD) as abdominal obesity has been linked with the metabolic syndrome. At the end of 12 weeks, the results demonstrated a decrease in body fat mass (BFM) of 1.73 kg in the group receiving CLA 3.4 grams (P ≤ .05) and a decrease of 1.3 kg in the group receiving 6.8 grams (P ≤ .05). In regards to weight loss, CLA is believed to work by promoting apoptosis in adipose tissue. Studies which included multiple products were not included due to inconclusive evidence of the effectiveness of individual products. 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