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Oppositely, oral administration of naringenin (14) to male rats for 10 weeks resulted in increased serum testosterone levels . In addition, icariin (11) also contributed to the increase of the expressions of peripheral-type benzodiazepine receptor (PBR) and steroidogenic acute regulatory protein (StAR), leading to increased testosterone production in adult-male rat testes . Quercetin (7), which does not have an extra hydroxyl in the position 5′ of the B-cycle as in myricetin (8), has been shown to improve steroidogenesis and testosterone levels in male mice exposed to bisphenol A, widely used in the production of plastics . 19.5.6 Psychotherapy Psychotherapy is often the first-line therapy for most patients with anxiety disorders (Table 19.4). Buspirone is a 5-HT1A receptor partial agonist that has been shown to be effective in the treatment of GAD and anxiety symptoms in depression. 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