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Over the last decade, the potential effects of vitamin D on fertility have been of great research interest as in vitro studies found that the vitamin D receptor is expressed in the ovary,40, 41 the endometrium,40 and the placenta.42 Animal studies have also pointed to a possible role of vitamin D in fertility as female rodents fed a vitamin D deficient diets and female rodents with knockouts for VDR and 1α-hydroxylase (which catalyses the hydroxylation of 25(OH)D into the biologically active 1,25(OH)2D) were shown to have reduced fertility43, 44 as a result of uterine hypoplasia, impaired follicular development and anovulation.45–47 The high prevalence of impaired fecundity combined with the high financial costs of and limited geographic access to infertility treatment motivate the need to identify modifiable predictors of couple fertility.7, 8 While there is a growing acceptance that nutrition may be related to reproductive performance in both men and women,9 there is still no official guidance for reproductive-aged couples. Intake of supplemental folic acid, particularly at doses higher than those recommended for the prevention of neural tube defects, has been consistently related to lower frequency of infertility, lower risk of pregnancy loss and greater success in infertility treatment. In contrast, a diet based on the recommendations of the MeD—rich in dietary fiber, ɷ-3 FAs, vegetable protein, vitamins, and minerals—has a positive effect on female fertility. There are no recommendations indicating the benefits of eliminating gluten from the diet of all women experiencing infertility. However, there are presently very few data regarding the use of sildenafil in women and the results are still conflicting. The engorgement of penile corpora cavernosa in men and clitoris and labia minora in women are the main modifications of genital organs during sexual arousal. This molecule promotes the relaxation of the smooth muscle cells, causes vasodilatation, and increases blood flow in genital organs. 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