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The continent is washed by the Mediterranean Sea to the north, the Red Sea to the northeast, the Atlantic Ocean to the west, and the Indian Ocean to the east and south. It is 5,000 miles (8,000 kilometers) long from north to south and 4700 miles (7,500 kilometers) long from west to east in the northern part. African regions are treated under the titles Central Africa, eastern Africa, North Africa, Southern Africa, and western Africa; these articles also contain the principal treatment of African historical and cultural development. While some areas appear to have been inhabited more or less continuously since the dawn of humanity, enormous regions—notably the desert areas of northern and southwestern Africa—have been largely unoccupied for prolonged periods of time. The onset may happen within 15 to 30 minutes, but the effects can last anywhere from 2 to 6 hours depending on the active ingredient and dosage. 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