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"Targeted curation of the gut microbial gene content modulating human cardiovascular disease." bioRxiv (2022). Urinary testosterone concentrations are higher in boys than in girls, and testosterone peaks in boys at 1 month of age, is lower before and after this age, and declines to baseline by about age 6 months. In addition, the sex difference in testosterone in infants appears to be largest at about the first to the second month of postnatal life and to be smaller before and after that, reaching baseline by about 6 months of age [13-15] (also see Figure 1). These, therefore, are the times when testosterone is likely to influence human gender development. Regarding potential pitfalls in studying gender, one is the tendency to analyze findings by gender, even when there was no initial hypothesis about gender differences . Therefore, investigating testosterone in humans at times when it shows dramatic sex differences provides the best opportunity to see any effects that might exist. 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