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Transgenic mice overexpressing human, bovine or rat GH genes exhibit excessive GH and IGF-1 concentrations resulting in a giant phenotype and organomegaly, including increased kidney weight even when related to increased body weight (Fig. 1) [114–119]. Since α-Klotho is not expressed in pituitary adenoma, elevated sKlotho levels are most likely due to increased renal α-Klotho and consecutively, enhanced cleavage of its extracellular domain as the main source of sKlotho (vide supra) [112, 113]. Circulating levels of sKlotho are markedly increased in acromegalic patients and return to normal in parallel with GH and IGF-1 levels after tumor removal [111, 112]. These findings are most likely related to GH-induced calcitriol synthesis (vide supra), with consecutively increased intestinal calcium absorption, as calcitriol levels tend to be elevated in these patients . 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