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Longa extract for 30 days reduced inflammationand muscle damage in marathon runners by increasing levels of theanti-inflammatory cytokine IL-10 and reducing the secretion of myoglobin.108 Another randomized trial demonstrated thatcurcuma extract restores ferritin levels and decreases hepcidin levels,which might help in combating iron deficiency and chronic inflammationin healthy individuals.109 In premenopausalwomen, a botanical supplement containing turmeric, when taken for12 weeks, decreased the levels of serum dehydroepiandrosterone,dehydroepiandrosterone-sulfate, androstenedione, and estrone-sulfate,thus improving hormone metabolism.110 Turmericformulations relieve abdominal pain in inflammatory bowel disease(IBD) and musculoskeletal and joint pain, and improve the symptomsof discomfort.111−113 One study suggested that consumption ofcurry containing 0.5 g turmeric remarkably increased breath hydrogenlevels, suggesting activation of hydrogen-producing gut microbiotaand improved bowel motility.114 Studieshave also shown that turmeric elevates serum insulin levels and providesantioxidant activity in healthy subjects.115,116 Moreover, C. 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Thetreatment was also found to be safe and effective.457 A curcumin formulation was also found to be highly tolerableand increased physical performance by reducing ESR and suppressingsoluble CD40 ligand (sCD40L), IL-1β, IL-6, and VCAM-1.458 In addition, administration of the curcuminformulation Meriva and glucosamine in 124 patients with osteoarthritisfor 4 months showed better improvement in outcomes.459 Moreover, consumption of a water-dispersible form of curcumin,Theracurmin 180 mg/day, in 41 osteoarthritic patients produced painrelief with no adverse effects.460 A daily1500 mg dose of the C3 curcuminoid complex in 40 osteoarthritic patientsfor 6 weeks markedly induced anti-inflammatory activity and producedimprovements in clinical outcomes by reducing serum levels of IL-4and hs-CRP.461 Furthermore, daily administrationof 1500 mg of C3 in combination with bioperine in 40 osteoarthriticpatients for 6 weeks relieved disease-related symptoms by inducingantioxidant activities and suppressing oxidative stress via downregulationof MDA and upregulation of SOD and GSH.462 Patients treated with CuraMed (containing 333 mg curcuminoids) andCuramin (containing 350 mg curcuminoids plus 150 mg boswellic acid)tolerated the treatments well, with no adverse effects, and experienceda reduction in pain-related symptoms. 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