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Testosterone also inhibits preadipocyte differentia tion into adipocytes.27,28 The effects of testosterone on myogenic differentiation in vitro are blocked by the AR antagonist bicalutamide, indicating that these effects are mediated through an AR pathway.27 It is possible that androgens might exert additional effects through nongenomic mechanisms. Some studies reported improvements in maximal voluntary strength8,11,12 and a decrease in fat mass (−0.7 kg, 95% CI −1.0 to −0.5).11,13,14,16 The search terms used were “hypogonadal men”, “testosterone” and “body composition”.8-17 We also searched the references of identified articles for further papers. The effects of testosterone on physical function and outcomes important to patients have not, however, been studied. In the United States and many other countries, government agencies that regulate medicines haven't approved testosterone therapy for women. 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