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The major involvement of dopamine versus noradrenaline in facilitating copulatory behavior was obtained by studies showing that low doses of apomorphine, a classical mixed dopamine D1/D2 receptor agonist, increased the number of rats showing mounts, intromissions and reaching ejaculation [35,36,195]. The availability of these new agonists and antagonists of the different dopamine receptors (in particular of the D2 family) (Table 3 and Table 4) also reopened the research for identifying the role of these receptor subtypes in the control of sexual behavior. These studies led to propose that dopamine and serotonin have an opposite role in sexual activity, the first facilitating and the second inhibiting sexual behavior in males [32,33,35,36,37,38,39,40,191], whereas both compounds were found to be inhibitory in females [41,42,43,44,192]. 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