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In addition to the endocrine control of LH and FSH on testicular function and sperm production, local testicular steroids, proteins, and peptides called paracrine-autocrine factors coordinate the various functions of the different testicular cell types and/or modulate the testicular actions of pituitary gonadotropins according to local conditions and requirements (Fig. 2-2). Plasma inhibin, E2, and estrogen conjugates (ECs) were significantly lower and gonadotropins significantly higher in idiopathic infertile stallions, whereas plasma T levels did not change.22 These findings suggest that FSH in the colt may be the hormone critical for Sertoli cell development and proliferation prior to puberty, whereas testosterone triggers Sertoli cell differentiation and maturation necessary for gene expression of various paracrine factors important for germ cell development. 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