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Interestingly, a clinical value of serum testosterone as a predictive factor for the development of MS was recently reported; a meta-analysis of longitudinal studies showed that the baseline testosterone level was 2.17 nmol/L lower in men with incident MS compared with controls (p73 At present, it is well accepted that a low serum testosterone level has emerged as a reliable prognosticator of MS in men whose testosterone deficiency is genetic or iatrogenic following surgery,67,74,75 or pharmacologically induced by gonadotropin-releasing hormone during prostate cancer treatment.76 Regarding this point, we reported previously that no inverse relation exists between adiponectin and testosterone levels in symptomatic older patients with LOH and that TRT does not affect adiponectin levels in older men.65 Thus, TRT, particularly in patients with LOH, does not appear to pose a large risk of inducing MS as a result of a decrease in serum adiponectin levels. Regarding diabetes, it is well known in urology that androgen deprivation therapy for patients with prostate cancer increases insulin resistance,40,41 and indeed, the serum total testosterone level is inversely related to the insulin concentration and insulin resistance in men.42 Several epidemiological studies in men have shown that a close association between a low serum testosterone level and type 2 diabetes mellitus (T2DM) has been reported.43-45 Recently, it was reported that about a third of men with T2DM present with LOH.46 However, the more interesting finding than that of a close relationship between low serum testosterone level and T2DM in cross-sectional studies is the fact that a low serum testosterone level is a precursor for the incidence of insulin resistance and T2DM, as shown in longitudinal studies of healthy men.47-49 When the efficacy of TRT for diabetes is considered, three recent large RCTs consistently showed a significant decrease in insulin resistance,50-52 although testosterone-induced changes in glucose metabolism still appear inconsistent and less pronounced than would be expected. 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