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The activation of hypothalamic-pituitary-testicular axis in puberty induces expression of androgen receptor (AR) and stimulates secretion of testosterone and DHT9,43,44, which finally lead the penile growth spurt9,43,45. Combined with our previous researches15,16, we concluded the penile length was improved by remodeling tunica albuginea. We further confirmed the lengthening effect by measuring exposed penile size, that Anti-LOX and Anti-LOX + VED increased length by 9% and 19%, respectively. As two classical molecular biomarker for erectile function assessment, eNOS and α-SMA were all similar among the seven groups, indicating penile erectile function was not impaired by Anti-LOX, HCG, or VED, whether alone or in combination (p 4). 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