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For continuous data, we expressed treatment effects as mean differences (MDs) with 95% CIs, unless different studies used different measures to assess the same outcome, in which case we expressed data as standardized mean differences (SMDs) with 95% CIs. Conventional treatment interventions included phosphodiesterase inhibitors (e.g. avanafil, sildenafil, tadalafil or vardenafil), injection (e.g. intracavernosal alprostadil), vacuum devices or psychosexual counseling (EAU 2020; Khera 2011).