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Therefore, it seems that the aging and the testosterone production decrease can lead to a progressive fibrotic process of the corpora cavernosa which is related to testosterone. As age advances the gonadal steroid hormones and, in particular, testosterone production decreases , nerve conduction slows and the efficiency of the vascular microcirculation of the penis is reduced. Recent experimental evidence showed that Testosterone also regulates the expression of phosphodiesterasis type 5 (PDE5) . In the animal model testosterone suppression lead to corpora cavernosum atrophy with concomitant structural alterations of the dorsal nerve of the penis, endothelial alterations, reduction of the smooth muscle component and increase in the deposition of extracellular matrix and cavernosal fibrosis. 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