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While there is no consistent definition or stratification of what features of a primary tumor are considered “high risk” for regional spread, there are a number of tumor- and patient-specific characteristics that can be used to guide management. Of these features, tumor grade now also contributes to the overall stage groups. Instead, a new list of “high-risk” features has been added, which impacts the overall T staging. Delagrange, P., Atkinson, J., Boutin, J. A., Casteilla, L., Lesieur, D., Misslin, R., Pellissier, S., Penicaud, L., and Renard, P. Therapeutic perspectives for melatonin agonists and antagonists. Cheung, R. T. The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion. Dericks-Tan, J. S., Schwinn, P., and Hildt, C. Dose-dependent stimulation of melatonin secretion after administration of agnus castus. Ardura, J., Gutierrez, R., Andres, J., and Agapito, T. Emergence and evolution of the circadian rhythm of melatonin in children. 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