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In general, greater absolute weight loss in kg was observed in subjects with higher baseline BMI for both semaglutide doses as well as for comparators, with the exception of insulin glargine in SUSTAIN 4. The model used to impute counterfactual values of body weight also included the interaction between treatment and each baseline variable and the interaction between any nausea or vomiting and each baseline variable. Transparency from manufacturers and a balanced, evidence-based approach to evaluating these products are crucial for protecting consumer health and promoting informed decision-making. Consumers should be aware of potential variations in product composition and quality across different brands and regions. Clear and comprehensive information regarding potential risks and contraindications is crucial for consumer safety. 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