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Overall, the onset of GI AEs is slightly higher in those trials designed to assess the efficacy and safety of GLP-1 RAs in people with obesity, which may be ascribed to the fact that doses are higher than those used in clinical trials in people with T2D. Finally, widely accepted myths and erroneous considerations concerning other AEs and profiles of subjects wrongly considered unfit to receive this medication are also reviewed to ensure that as many patients as possible can benefit from treatment with GLP-1 RA. More importantly, the better management of GI AEs could potentially have a positive impact on the adherence/persistence, effectiveness of treatment and quality of life (QoL) among GLP-1 RA-treated patients. Expert opinions provide a balanced perspective and reinforce the importance of a comprehensive approach to weight loss and overall health. However, adherence to the ketogenic diet can vary among individuals, and long-term sustainability may be a challenge for some. 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