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The authors provided sufficient information in the methods section so that, by consensus between the reviewers (RM/PB/LF), we were confident to include the study for extraction and analysis. Disagreements in study eligibility, data extraction, and quality assessment were resolved by consensus between the two reviewers. We searched PubMed/Medline, Embase and Google Scholar for studies published before March 29, 2022 that analyzed the quality and quantity of AAS to determine the proportions of substandard and counterfeit products found on the black market. To further determine the proportions of fake AAS found on the black market, we conducted a systematic literature review and meta-analysis of analytical test results for those substances within the published literature. 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Current research shows comparable efficacy when the active ingredients and dosages are equivalent. Weight‑loss gummies are generally regarded as safe when consumed within studied dosage limits. Individual response is influenced by genetics, gut microbiota composition, baseline diet, and concurrent medications, underscoring the need for personalized assessment. Strongest data exist for fiber‑induced satiety and modest thermogenic effects of catechins; evidence for HCA and chromium is emerging and often confounded by study design limitations. However, the term "best and safest" is context‑dependent; superiority claims are rarely backed by head‑to‑head trials, and safety profiles differ across ingredients and population groups. Scientific interest has risen because gummies can encapsulate both traditional nutraceuticals (e.g., chromium picolinate) and newer botanical extracts (e.g., bitter orange). 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