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Some statistical solutions are offered for assessing case studies (e.g., the Crawford t-test; (Corballis, 2009)).”– 'that were not replicated' – Yes, we should be especially skeptical if a second well-powered experiment failed to replicate the first, but I would only be normally skeptical of a single-experiment finding, regardless of its sample size. Rank correlations help us mitigate this problem to a degree, because it doesn’t require us to verify any assumptions, and have been shown to be more robust for small sample sizes (Mundry and Fischer, 1998) (though we note that Spearman is also sensitive to outliers (Rousselet and Pernet, 2012)). Also, keep in mind that CBD products aren't standardized and will vary. Dispensary products must be labeled so you can see exactly how much CBD is in the product and whether it also contains THC. 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