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Isolate CBD gummies have minimal or no hempy taste, but they don’t produce synergistic effects. Two [54, 61]of the poor quality studies favored melatonin, whereas the third favored neither melatonin nor control. Fifteen [28, 49–61, 63] RCTs with a total of 223 participants described melatonin use for promoting sleep in healthy volunteers. Melatonin appears to be relatively safe based on the six [38, 39, 41–44] studies that reported adverse events, citing occasional, but not serious adverse events and interactions. Despite its apparent safety, and the general high quality of this literature pool, sample sizes were generally small, and results inconclusive, with no magnitude of an estimate of effect size reported. Results indicated that both of the poor quality studies favored melatonin [31, 32] however, all of the high and highest quality studies were inconclusive [29, 30, 33–36] in that they favored neither melatonin nor the control. 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